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Author Topic: Funding Announcement for predictive multiscale models for biomedical research  (Read 1069 times)
Sherry Ward
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« on: January 12, 2015, 06:52:08 pm »

Funding Opportunity Announcement:
Predictive Multiscale Models for Biomedical, Biological, Behavioral, Environmental, and Clinical Research (PAR-15-085):

The goal of this interagency funding opportunity announcement (FOA) is to support the development of multiscale models to accelerate biological, biomedical, behavioral, environmental and clinical research. The NIH, ARO, DOE, FDA, NASA, NSF, and ONR recognize that in order to efficiently and effectively address the challenges of understanding multiscale biological and behavioral systems, researchers will need predictive, computational models that encompass multiple biological and behavioral scales.  This FOA supports the development of non-standard modeling methods and experimental approaches to facilitate multiscale modeling, and active participation in community-driven activities through the Multiscale Modeling (MSM) Consortium:

Multiscale modeling uses mathematics and computation to quantitatively represent and simulate a system at more than one scale while functionally linking the mathematical models across these scales.  This FOA is focused on biological and behavioral scales, which include atomic, molecular, molecular complexes, sub-cellular, cellular, multi-cell systems, tissue, organ, multi-organ systems, organism/individual, group, organization, market, environment, and populations. Multiscale models of biological and behavioral systems can be used as important tools to address a range of biomedical, biological, behavioral, environmental, and clinical problems. Multiscale modeling and analysis methods can provide fundamental infrastructure for understanding and predicting biological and environmental processes; diseases; and human and organizational behavior patterns and outcomes….

Earliest receipt date is March 9, 2015 with Letter of Intent due February 9, 2015.

Application Due Date(s)
March 9, 2015; May 29, 2015; September 29, 2015; January 29, 2016; May 30, 2016; September 29, 2016; January 30, 2017; May 29, 2017; September 29, 2017

Letter of Intent Due Date(s)
30 days before the Application Due Date

This FOA uses the U01 cooperative agreement activity code.

Award Budget
Budgets are expected to range from $200,000 to $400,000 in Total Direct Costs each year…

Award Project Period
The maximum award project period is 5 years.

Eligible Organizations
Higher Education Institutions; Nonprofits; For-Profit Organizations; Governments

Several examples of specific interests of participating agencies – more are provided in the FOA:

National Institute of Biomedical Imaging and Bioengineering is interested in supporting the development of predictive multiscale models that have broad diagnostic, therapeutic and interventional applications in diseases or health conditions. Areas of interest include multiscale modeling to complement technology development in all other program areas of the NIBIB, such as medical device development and testing, rehabilitation engineering, surgical techniques, drug and gene delivery, tissue engineering, sensor and microsystems, synthetic biology, and biointerfaces,

National Human Genomic Research Institute is interested in the development of multiscale models to predict the effects of genomic variation in coding and noncoding regions and epigenetic modification on the transmission of information and events across scales, such as in gene expression, cellular state, disease status, and gene-environment interactions on organismal phenotypes in humans or model organisms; as well as to support the development of major advances in DNA sequencing or other high-throughput genomic technologies.

Eunice Kennedy Shriver National Institute of Child Health and Human Development is interested in research that makes use of computational, mathematical, or engineering models to deepen our understanding of the multiscale biomedical, biological, clinical, behavioral and social processes associated with health, disability, and developmental outcomes from pre-conception into adulthood. … [An example would be] multiscale models of developmental processes for explaining embryogenesis and/or organogenesis through understanding the networks of interacting components (i.e. molecules, cells, tissues or organs) on a whole cell, tissue, organ, or organism-wide basis.

U.S. Army Research Office, Biomathematics Program is interested in basic, high-risk, high-reward research that uses, develops, and analyzes mechanistic multiscale mathematical models to uncover fundamental relationships in a wide variety of biological systems….

U.S. Food and Drug Administration is interested in development of predictive multiscale models of physiology and pathophysiology that improve our understanding of the performance of medical products, such as medical devices or medical pharmaceuticals, in humans.  To facilitate more effective medical product development, improved methods are needed to predict whether a proposed medical product design will function properly and safely. Computational modeling should be integrated with in vitro and in vivo experiments and/ or clinical studies in such a way that these distinct elements and their interplay will provide a more informative medical product evaluation pathway….
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